Despite significant advances in medical care and nutrition, there is a growing need to develop novel strategies to improve cutaneous wound healing. The medical field is rapidly advancing towards the development of low or non-invasive procedures and accelerated treatments that can achieve a reduced morbidity and a good functional recovery in our patients to improve their quality of life.
The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing: A Systematic Review and Meta-analysis With Bias Assessment.
Autologous US-guided PRP injection versus US-guided focal extracorporeal shock wave therapy for chronic lateral epicondylitis: A minimum of 2-year follow-up retrospective comparative study.
The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis
The Effectiveness of Platelet-Rich Plasma Injections in Gluteal Tendinopathy: A Randomized, Double-Blind Controlled Trial Comparing a Single Platelet-Rich Plasma Injection With a Single Corticosteroid Injection.
Repeated intravesical injections of platelet-rich plasma are effective in the treatment of interstitial cystitis: a case control pilot study.
Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata.
The study was completed by 150 patients, and a total of 150 foot ulcers were assessed. Wound size reduction was detected in patients after four weeks of treatment. In DFUs with a 2-5.5 cm2 surface area, complete closure happened after 7.2 weeks, 5.5-8.5cm2 DFUs completely closed after 7.5 weeks, and 8.5-12.5cm2 DFUs healed completely after 8.8 weeks. None of the wounds reopened after eight months of monitoring.
The Los Angeles Angels' newly signed two-way star, Shohei Ohtani, had a platelet-rich plasma injection in his right pitching elbow in October, according to multiple reports.
Documentation of Ohtani's medical history was circulated to major league teams pursuing the free-agent Japanese baseball star, according to a report by Sports Illustrated, which added that Ohtani's agent told teams such injections often are used in Japan as a preventive measure.
Ohtani has a first-degree sprain of the ulnar collateral ligament, according to a physical report obtained by Yahoo Sports. But Angels general manager Billy Eppler told Yahoo Sports, "We are pleased with the results of the physical, and we are very happy to have the player."
RESULTS:
The PRP group showed a significant reduction in the WOMAC-pain and -total scores compared to normal saline group (p < 0.05). Although a significantly greater percentage of knee strength (extensor > flexor) was found in the PRP group during a longer follow-up period, PRP treatment resulted in insignificant differences in muscle strength compared to normal saline.
CONCLUSIONS:
PRP treatment significantly improves pain, stiffness, and disability in patients with knee OA compared to normal saline treatment. Additional strength training is recommended to enhance muscle strength recovery.
The researchers found that hair density was significantly improved at day 28 and at month six for PRP versus PS (P = 0.0156 and 0.0313, respectively) and PPP (P = 0.042 and 0.046, respectively). There was significant histological improvement between day 28 and month six for PRP versus PPP and PS for vessels (P = 0.0160 and 0.021, respectively), collagen (P = 0.0036 and 0.032, respectively), and epithelium (P = 0.0138 and 0.022, respectively). There was no local toxicity.
"Our study suggests that subcutaneous PRP injections using controlled concentration of platelets and leukocytes improve hair growth," the authors write.
Single Platelet-Rich Plasma Injection for Early Stage of Osteoarthritis of the Knee
Conclusion Treating knee OA with PRP injection is safe. A single dose of PRP seems to be effective in managing pain and improving quality of life in patients with low-grade knee OA.
An Autologous Leukocyte-Reduced Platelet-Rich Plasma Therapy for Chronic Injury of the Medial Collateral Ligament in the Knee: A Report of 3 Successful Cases
Platelet-Rich Plasma for Primary Treatment of Partial Ulnar Collateral Ligament Tears: MRI Correlation With Results
Ouf of 23 primary injury patients who received PRP injections and nonoperative measures, 22 (96%) were able to return to play and demonstrated reconstitution of the MUCL on MRI.
Ian Rapoport of NFL Media reports that Winston had platelet rich plasma injections in his shoulder a couple of weeks ago and that he has shown improvement of late. He’s set for an MRI on Monday and there’s optimism that the results will push him closer to a return to the lineup.
Efficacy of subcutaneous injection of platelet-rich plasma in alopecia: A clinical and histological pilot study on a rat model with a six-month long-term follow-up experience.
PURPOSE:
To assess the potential of platelet-rich plasma (PRP) subcutaneous injection of to treat alopecia and to evaluate local toxicity.
RESULTS:
Hair density was significantly improved at D28 and at M6 for PRPQ+ vs PSQ+ (respectively, P = .0156 and P = .0313), PPPQ+ (respectively, P = .042 and P = .046). Significant histological improvement was observed between D28 and M6, for PRPQ+ vs PPPQ+ and PSQ+ for vessels (respectively, P = .0160 and P = .021), collagen (respectively, P = .0036 and P = .032), and epithelium (respectively, P = .0138 and P = .022) with no local toxicity.
CONCLUSION:
Our study suggests that subcutaneous PRP injections using controlled concentration of platelets and leukocytes improve hair growth.
SOURCE https://www.ncbi.nlm.nih.gov/pubmed/29130636
Buccaneers head coach Dirk Koetter told SiriusXM NFL Radio on Friday that Winston received a platelet-rich plasma injection about a week ago to address the AC joint sprain in his throwing shoulder.
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychological and emotional well-being. Hair restoration technologies have advanced with the use of robotics and manual and motorized follicular unit extraction to provide patients excellent clinical results. Adjuvant modalities such as platelet-rich plasma injections, lasers and stem cells can further enhance the survivability and appearance of hair transplants.
Dermatol Clin. 2018 Jan;36(1):57-62. doi: 10.1016/j.det.2017.09.008.
In the present retrospective study assessing PRP injections in the treatment of chronic tendinopathy, a moderate improvement (>50%) in pain symptoms was observed in most of the patients. Our research found that results were most promising with patellar and lateral epicondylar tendinopathy in the short to medium term. Female patients, patients with upper extremity tendinopathy and older patients appeared to benefit more from PRP injection.
