PRP & Rotator Cuff

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In vivo clinical and radiological effects of platelet-rich plasma on interstitial supraspinatus lesion: Case series

Results

Tear volume diminution was statistically significant (P = .007), and a >50% tear volume diminution was observed in 15 patients. A statistically significant improvement of Constant score (P < .001), SANE score (P = .001), and VAS (P < .001) was observed. In 21 patients, Constant score improvement reached the minimal clinical important difference of 10.4 points

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PRP & Knee Osteoarthritis

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Abstract

Background

 

A randomized clinical trial was conducted on 89 patients with KOA. The patients were given either PRP (n = 45) or HA (n = 44) intra‐articular injections.

Results

While both PRP and HA injections resulted in the improvement of all outcome measures at 3 and 6 months follow up, they were significantly better in the PRP group than in the HA group.

Conclusion

Intra‐articular injection of PRP is an effective treatment that reduced pain and improved functional status in patients with KOA. The clinical outcomes of the intra‐articular injections of PRP are associated with improved synovial hypertrophy and vascularity scores, and less effusion.

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PRP & Frozen Shoulder

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Int J Clin Pharmacol Ther. 2018 Jun 22. doi: 10.5414/CP203262. [Epub ahead of print]

Lin J.

Abstract

PURPOSE:

Platelet-rich plasma (PRP) has been utilized in the treatment of chronic injuries. The current study aimed to evaluate the efficiency of PRP in the treatment of frozen shoulder compared to procaine.

PRP and procaine were effective in treating frozen shoulder. PRP was more effective and had a more prolonged efficiency than the procaine control. Nevertheless, the definite conclusion should come from further large-scale clinical trials.
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Platelet rich plasma for the management of hair loss: Better alone or in combination?

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Eduardo Anitua PhD, MD, DDS, Ander Pino MSc, Pedro Jaén PhD, MD, Mª Rogelia Navarro MD

First published: 14 June 2018 https://doi.org/10.1111/jocd.12683

Summary

Platelet‐rich plasma (PRP) and autologous protein‐based treatments have recently emerged as a potential therapeutic approach for hair loss‐related disorders including androgenetic alopecia and alopecia areata. The safety and efficacy of repeated intradermal injections of PRP has proved to promote hair growth in a number of randomized clinical trials. Biologically active proteins and cytokines released upon platelet activation have shown to induce folliculogenesis and activate the anagen growing phase of dormant bulbs. Interestingly, further studies have revealed that combining PRP with other hair loss‐related products may enhance the final performance of the treatment. These synergistic approaches include Food and Drug Administration (FDA) approved drugs such as finasteride or minoxidil, bioactive macromolecules and cell‐based therapies. Here, recent research involving alone or combined therapy with platelet‐rich plasma for the management of hair loss‐related disorders are outlined and future prospects are discussed.

PRP & Osteochondritis Dissecans

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Osteochondritis Dissecans
Does platelet rich plasma really help?

Deepak Kumar SharmaCorrespondence information about the author Deepak Kumar Sharma, Narendra Kumar, Hitesh lalEmail the author Hitesh lal, Binay Kumar Sahu, Sumon Singphow Saikia

Osteochondritis dissecans is a common disorder of knee and can be treated by various methods, depending on age of patient and stability of chondral fragment. In Osteochondritis dissecans ICRS type III lesion i.e. articular cartilage discontinuity but no dislocation, variable rate of union as well as high rate of non-union was observed in previous studies when treated with arthroscopic or open reduction and fixation. In previous study it has been also shown that platelet rich plasma help in fracture healing. In this study we are trying to extend the benefit of platelet rich plasma to Osteochondritis dissecans lesion. We took six patients with OCD, ICRS scale of OCD type III lesion. All Patients were operated Arthroscopiclly. Chondral flap of OCD lesion were fixed with stainless steel cannulated cancellous screw. To enhance union we used platelet rich plasma injections. .We access the union of chondral fragment to parent bone and knee function. Chondral fragment united to parent bone in all patients. To access knee function we used Tagner- Lysholm knee scoring system, in this study preoperatively score was 52.8 where as postoperatively it was 91.8. This study showed PRP is helpful in healing of chondral flap as all the chondral flap of osteochondral lesion united in this study.

Angels Star Shohei Ohtani Is Avoiding Tommy John Surgery ... For Now

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Los Angeles Angels star Shohei Ohtani received platelet rich plasma (PRP) and stem cell injections for a Grade 2 ulnar collateral ligament (UCL) injury in his elbow this week. At the very least, this is a short-term problem for Ohtani, but it may also be a harbinger of a much bigger issue. What concerns me is Ohtani’s history of UCL issues: In late 2017, he had a Grade 1 UCL sprain treated with a PRP injection.

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Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: a randomised controlled, pilot study.

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Results:  A total of eight patients, each with at least a six-month history of venous leg ulcer (VLUs), were included in the study. A total of 12 ulcers were treated with either autologous PRP or standard SoC. Patients treated with PRP required wound care only once per week. In the SoC group, patients required intervention 2–3 times per week. A reduction in the mean ulcer size in the PRP group was 3.9cm2 compared with the SoC group at 3.2cm2, although the sample size was insufficient to reach statistical significance. Improvement in quality of life (QoL) score was observed in the patients in the PRP group.

Conclusion:  This study offers proof-of-concept of the feasibility and safety of PRP treatment to inform larger clinical trials in patients with VLUs. Our preliminary results suggest that PRP delivers a safe and effective treatment for VLU care that can be implemented in primary health-care settings.

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PRP & Talar Osteonecrosis

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Successful Treatment of Early Talar Osteonecrosis by Core Decompression Combined with Intraosseous Stem Cell Injection: A Case Report

Case Report:

We report a successful treatment of early talar osteonecrosis ARCO I (Association Research Circulation Osseous) by core decompression combined with stem cell and PRP injection. On 3-month and 15-month follow-up, MRI showed complete resolution of the osteonecrotic changes together with clinical improvement.

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PRP & Knee Osteoarthritis

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[Effect of intra-articular injection of platelet-rich plasma on interleukin-17 expression in synovial fluid and venous plasma of knee osteoarthritis patients].

Conclusion:

Intra-articular injection of PRP can significantly release the pain symptoms, improve joint function, and reduce IL-17 levels in both synovial fluid and venous plasma of the patients with knee OA, but IL-17 levels can not reduce to normal level.

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Platelet-rich plasma on female androgenetic alopecia: Tested on 10 patients.

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RESULTS:

After 24 weeks, the median relative percentage change (%RC) for all the parameters of hair density was mostly positive. After 12 weeks, the medium hair diameter in frontal area showed a significant increase (%RD = 12.5, with P-value < .05), and after 24 weeks (%RD = 14.6, P-value < .05), the vellus relative change instead showed a decrease, especially in the front and the central area, while for the vertex, the decrease was mainly visible at the end (-6.6%). No adverse events were reported.

CONCLUSION:

Platelet-rich plasma injections have a positive therapeutic effect on hair density and hair diameter improvement.

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