A total of 31 patients were recruited under the assumption of a 20% dropout rate, 20% size effect from treatment, bilateral 5% alpha risk, and 80% beta risk. The mean age of the 31 patients included in the study was 51.8 plus or minus 8.5 years. Comparison of FACE-Q scores showed significant improvement at 6 months compared with baseline.
Platelet-rich plasma makes it possible to heal painful knee injuries, using a person's own blood.
Athletes such as Tiger Woods and Rafael Nadal are rumored to have undergone a relatively new treatment that involves injections of platelet-rich plasma. Proponents say the therapy offers cutting-edge treatment for previously debilitating injuries, including painful knee problems due to osteoarthritis.
Conclusion:
Activated platelet-rich plasma reduces articular damage as evident at MRI, as soon as six months after treatment; it reduces pain and improves patient’s function and overall quality of life.
The topical use of autologous platelet-rich plasma as monotherapy is an effective treatment to improve signs and symptoms in patients suffering from moderate to severe chronic DED.
CONCLUSIONS:
Evidence from the current literature, although limited, suggests that the use of PRP may result in an earlier return to sport among patients with acute grade I or II muscle strains without significantly increasing the risk of reinjury at 6 months of follow-up. However, no difference in time to return to sport was revealed when specifically evaluating those with a grade I or II hamstring muscle strain.
In conclusion, CIA mice treated with PRP exhibited beneficial effects, including decreased joint inflammation, cartilage destruction and bone damage, and increased repair of joint tissue. The results of the present study suggested that PRP may be an effective therapeutic agent for RA.
METHOD:
Patients with mild to moderate AGA, aged 18-45 years with Hamilton-Norwood score 1-5 were included in both study and control group. Dermoscopy was performed using Dermlite II hybrid m; 3Gen dermoscope at 10× magnification in polarized mode, and photographs were taken. Those not responding or those not having any new hair growth to conventional therapy for at least 1 year were included. The study group were given autologous platelet-rich plasma injections with microneedling over a period of 3 months at 3 weekly interval. Baseline and post-treatment photographs were taken.
RESULT:
Hair growth started after the first session. The patients' satisfaction was more than 75% in 18 patients, on patients' subjective hair growth assessment scale. In post-PRP-treated patients of AGA, increase in the number of vellus and total hairs, increased hair shaft diameter, and reduction in yellow dots were appreciated after 3 sessions. Hair pull test was negative after treatment in 14 patients (70%).
This study showed homologous PRP could be safely used without complications or adverse effects. Additionally, all of the patients reported a significant satisfication from the treatment.
Recently, an injection of autologous platelet rich plasma has been reported to be effective for both intermediate and long term outcomes for the treatment of lateral epicondylosis.
Results
After one session of therapy, fading of hyperpigmentation marks was noted and the patient’s face looked more supple (Figure 2). Healing of acne pustules and papules was also noted. Reduction in prominence of boxcar and rolling acne scars was observed following second session of therapy. A transition to Grade 1 (mild acne scars) was noticed after the third session of therapy the results of which have been maintained till date (Figure 3).
Redding, a promising young centerback for Orlando City, braved his fears and went in July 5 for a platelet-rich plasma injection, also known as PRP.
Platelet-rich plasma in combination with 5% minoxidil solution showed efficacy in hair regrowth for patients with androgenetic alopecia compared with the combination with oral finasteride, according to study results recently published in Dermatologic Surgery.
Researchers studied 25 patients with androgenetic alopecia (13 females; mean age, 39.9 years). Thirteen patients were treated with 1 mL 5% topical minoxidil solution twice daily and 12 patients treated with 1 mg per day of oral finasteride.
Learn more: Journal of Clinical Neuroscience
Introduction: Periarthritis (PA) shoulder characterised by pain and restricted range of motion has a plethora of treatment options with inconclusive evidence. Platelet Rich Plasma (PRP) is an emerging treatment option and its efficacy needs to be examined and compared with other routine interventions.
Results: PRP treatment resulted in statistically significant improvements over corticosteroid and ultrasonic therapy in active as well as passive range of motion of shoulder, VAS and QuickDASH at 12 weeks. At six weeks, PRP treatment resulted in statistically significant improvements over ultrasonic therapy in VAS and QuickDASH. No major adverse effects were observed.
Conclusion: This study demonstrates that single injection of PRP is effective and better than corticosteroid injection or ultrasonic therapy in treatment of PA shoulder.
INTRODUCTION:
Despite an adequate orthopedic treatment with functional bracing, some patients develop a delayed union in humeral shaft fractures. The objective of the present study was to determine the bone consolidation time among patients with delayed union of diaphyseal humeral fractures who were managed with locking compression plate (LCP) fixation combined with an iliac crest autograft using platelet-rich plasma (PRP) as a co-adjuvant.
RESULTS:
A total of 16 patients were included. Both groups had similar demographic characteristics. The patients treated with PRP had an earlier beginning of bone consolidation. Furthermore, these same patients exhibited bone consolidation at 19.9 weeks, on average, in contrast to 25.4 weeks in the control group.
CONCLUSIONS:
The use of PRP promotes earlier bone consolidation in patients with delayed union of the humeral shaft.
RESULTS:
Six months after treatment with PRP, patient's with elbow epicondylitis had a significant improvement in their VAS (P < 0.05) and MAYO (P < 0.05) in contrast to steroid, whereas no statistical difference was found between the two groups at 1 and 2 months after intervention.
CONCLUSION:
Treatment of patients with epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection.
Source: International Journal of Applied Basic Medical Research
Autologous platelet biomaterials represent a key source of cytokines and growth factors extensively used for clinical and surgical applications involving tissue regeneration; wound healing and tissue repair. In this communication we discuss the growth factors released by activated platelet rich plasma (PRP) and platelet rich fibrin (PRF) releasate. Our study highlights that significantly higher growth factors (TGF-ß1) are released by activated PRP as compared to releasate of PRF. The various growth factors released by both platelet products are significantly higher than the baseline concentration in the whole blood and have different bio-mechanism hence should be individualized as per the clinical indication.
Source https://www.ncbi.nlm.nih.gov/pubmed/28596670
The use of PRP rich in platelets and poor in leukocytes can provide objective improvements in skin biostimulation,” the researchers concluded. “Although a pilot study, our results may be useful for future studies on the specific cells and growth factors in PRP that contribute the facial rejuvenation.” – by Bruce Thiel
RESULTS:
Overall, 49 females and 31 males were included with thirty elbows in each group. Both the PRP and triamcinolone groups had better pain relief at 3 and 6 months as compared to normal saline group (P < 0.05), but at 6 months followup, the PRP group had statistically significant better pain relief than triamcinolone group. In the triamcinolone group, 13 patients had injection site hypopigmentation and 3 patients had subdermal atrophy.
CONCLUSION:
Over a short term period, PRP gives better pain relief than triamcinolone or normal saline in tennis elbow which needs to be validated over long term period by further studies.
Washington Wizards forward Kelly Oubre Jr. received platelet-rich plasma injections in his right knee Friday in Los Angeles, according to several people close to the situation.
Oubre, a second-year player who played through pain during the Wizards’ playoff run, is not expected to undergo further injections and will sit out the next few weeks to rest his knee. Although Oubre could resume basketball activities later this month but will not play with the Wizards’ Summer League team in July.
