Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series.

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BACKGROUND:

Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. PRP is a conglomeration of thrombocytes, cytokines and various growth factors which are secreted by α-granules of platelets that augment the rate of natural healing process with decrease in time. The purpose of this case series was to evaluate the safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers on the lower extremity.

CONCLUSION:

This case series has demonstrated the potential safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers.

Read about this clinical study.

Personalized plasma-based medicine to treat age-related diseases.

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As social and health needs are changing, new challenges to develop innovative alternatives arise to address unmet medical needs. Personalized medicine is emerging as a promising and appealing therapeutic option. The use of patient's own plasma and platelets as therapeutics is providing new avenues in the treatment of acute and chronic tissue injuries by promoting tissue repair and regeneration.

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Editorial Commentary: The Time Has Come to Try Intra-articular Platelet-Rich Plasma Injections for Your Patients With Symptomatic Knee Osteoarthritis.

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Abstract

Platelet-rich plasma injections, in a systematic review and meta-analysis of 10 Level I randomized control trials, were found to provide more pain relief and better functional outcomes than hyaluronic acid in patients with knee osteoarthritis at 12 months after injection. The time has come for those of us who have not yet tried platelet-rich plasma injections in our patients with symptomatic knee osteoarthritis to do so.

Source Pub Med

The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study.

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OBJECTIVE:

The objective of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGFs) for the treatment of androgenetic alopecia (AGA).

MATERIALS AND METHODS:

Five PRGF injections were administered over 19 patients with AGA. Phototrichograms regarding follicle density/diameter and terminal/vellus hair ratio were performed at baseline and after 1 year follow-up period. Consenting participants underwent histologic scalp examination. At the end of the study, overall patient satisfaction and clinical improvement were determined.

RESULTS:

After PRGF therapy, mean hair density/diameter increased and terminal/vellus hair ratio was also improved. Patients presented epidermal thickness, perifollicular neoangiogenesis, cell proliferation, and terminal/miniaturized hair ratio improvement. Plasma rich in growth factors seemed to reduce the perivascular inflammatory infiltrate, promote the remodeling of dermo-epidermal tissue, and increase bulge stem cell niches. Patients declared an overall positive satisfaction, and a high clinical improvement score was achieved when comparing premacrophotographs and postmacrophotographs.

 

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Procedure allows women to go ‘under the needle’ to boost bustlines

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FREDERICKSBURG, Va. (WRIC) — Emily Neumann is always on the go. The 23-year-old balances being a mom and occupational therapy student with her social life.

“I have a friend’s wedding, so I want to look good in my dress,” she says with a smile.

That desire brought her to Dr. Anne Truong‘s office for something called a Vampire Breast Lift.

“The moment I finish, I hear a wow,” says Dr. Truong. “They love it.”

A Vampire Breast Lift uses the patients own blood. A centrifuge separates the platelet rich plasma (PRP). It is then mixed with filler in a syringe.

“You get a natural glow, smoothness and reshaping of the cleavage that is very natural,” describes Dr. Truong, who is a physiatrist.

PRP injections have been used in some orthopedic and dental offices for years based on the idea they stimulate the body’s natural healing response and promote collagen production. That effect can add volume to a treatment area, according to Dr. Truong.

“It doesn’t replace breast implants but certainly it’s an opportunity for you to feel confident,” she explains.

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Conservative Treatment of Ankle Osteoarthritis: Can Platelet-Rich Plasma Effectively Postpone Surgery?

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We retrospectively evaluated the mid- to long-term clinical results (mean follow-up of 17.7 months) for platelet-rich plasma injections in 20 patients (20 ankles) with ankle osteoarthritis. We evaluated the presence of pain using the visual analog scale, function using the Foot and Ankle Disability Index, and subjective satisfaction. The pre- and post-treatment scores, obtained from the clinical records and from telephone interviews during the follow-up period, were compared using the Student t test. We found a strong positive effect for 4 platelet-rich plasma injections (injected once a week) on pain (p = .0001) and function (p = .001), with 80% of patients very satisfied and satisfied, and only 2 patients (10%) required surgery because of early treatment failure. These results suggest that the use of platelet-rich plasma injection is a valid and safe alternative to postpone the need for surgery.

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Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage.

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RESULTS:

PRP increased significantly the proliferation of chondrocytes, decreased apoptosis and increased autophagy and its markers along with its regulators FOXO1, FOXO3 and HIF-1 in osteoarthritic chondrocytes. Furthermore, PRP caused a dose-dependent significant decrease in MMP3, MMP13, and ADAMTS-5, IL-6 and COX-2 while increasing TGF-β, aggregan, and collagen type 2, TIMPs and intracellular IL-4, IL-10, IL-13.

CONCLUSION:

These results suggest that PRP could be a potential therapeutic tool for the treatment of OA.

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Orioles’ Chris Tillman on shoulder rehab: ‘I want to do it right. I’m not going to rush it’

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Chris Tillman entered the offseason hoping the right shoulder injury that resulted in a rare trip to the disabled list for three weeks late last season was behind him. But when the Orioles ace felt discomfort in his shoulder in mid-December, his attention immediately turned to ensuring he could resolve the problem before it lingered into 2017.

This year’s extended spring training — a result of the World Baseball Classic — will give him more time. But the Orioles’ timetable for Tillman’s return after a platelet-rich-plasma injection projects that he will be unable to make a fourth consecutive Opening Day start on April 3 against the Toronto Blue Jays; instead having him return to the rotation shortly thereafter.

Andrew Bogut could be out until after All-Star break after receiving platelet rich plasma injection in leg

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Andrew Bogut is recovering from the platelet rich plasma injection he took last week in his right leg and said he expects to be back on the court as soon as possible, but perhaps not until after the All-Star break.

It’s the second time Bogut has had such an injection, which takes a portion of his own blood having a platelet concentration above baseline to promote healing of injured tendons and muscles. He had it in a knee two years ago at Golden State.

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Immediate post-extraction implants with or without pure platelet-rich plasma: a 5-year follow-up study.

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CONCLUSIONS:

P-PRP implant group showed a better soft tissue management and wound healing in the first 7 days after surgery compared to non-P-PRP implant group. In the medium-term follow-up, comparable clinical and radiographic outcomes were noticed between two groups.

 

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Ian Mahinmi returns to practice: ‘I feel like I’m fixed’

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On Friday, Mahinmi, 30, was back at the familiar position — fresh off his first live action since undergoing platelet-rich plasma on both knees more than a month ago. Mahinmi practiced with no limitations and even played halfcourt five-on-five. This time, unlike the other false starts, Mahinmi feels more confident about his return to the lineup.

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Benefit of Leukocyte- and Platelet-Rich Plasma in Operative Wound Closure in Oral and Maxillofacial Surgery.

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Abstract

This article reports the influence of an autologous leukocyte- and platelet-rich plasma (L-PRP) injection as a minimally invasive method on supporting wound healing processes after a mandibular odontogenic cystectomy and double mandibular fracture fixation. 113 patients were enrolled into a control group...

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The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis.

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CONCLUSIONS:

Intra-articular PRP injections probably are more efficacious in the treatment of knee OA in terms of pain relief and self-reported function improvement at 3, 6 and 12 months follow-up, compared with other injections, including saline placebo, HA, ozone, and corticosteroids.

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Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease.

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Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. The SVF contains a mixture of cells including ADSCs and growth factors and has been depleted of the adipocyte (fat cell) population. We evaluated the safety and efficacy of administering SVF and PRP intra-discally into patients with degenerative disc disease.

 

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Topical use of platelet-rich plasma can improve the clinical outcomes after total knee arthroplasty: A systematic review and meta-analysis of 1316 patients.

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Platelet-rich plasma (PRP) is extracted by centrifuging whole blood and characterized with a high concentration of platelets. The purpose of this systematic review and meta-analysis of randomized controlled trials (RCTs) and non-RCTs is to evaluate the efficacy and safety of platelet-rich plasma (PRP) versus placebo after total knee arthroplasty (TKA).

 

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Platelet Rich Plasma Market-echnological advancements and regulatory approvals for new devices are contributing to the growth of the PRP market

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Platelet rich plasma (PRP) is a blood plasma product that contains elevated level of platelets and growth factors (at least four to ten times) than normal blood concentration. PRP is also called as also called platelet enriched plasma and platelet gel. While mostly derived from patient’s own blood, platelet rich plasma is widely used in the treatment of diseases such as orthopedic diseases, neurological diseases, and other minor injuries that require outpatient surgeries. Rising incidence of diseases such as orthopedic diseases, sports injuries, cardiovascular diseases, obesity, and neurological diseases and introduction of various devices for PRP preparation are the key factors that are likely to drive market growth.

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